COAGADEX is a High-Purity Factor X Product
COAGADEX has low levels of proteins other than factor X
Pre-ATI/IATI, pre-alpha-trypsin inhibitor/inter-alpha-trypsin inhibitor.
- Laboratory tests for potential thrombogenicity did not detect factor Xa or factor IIa
COAGADEX is the first and only product that is manufactured based on a factor X assay2
- Factor X content in Prothrombin Complex Concentrates (PCCs) is an estimate based on historical measurements and a factor X assay level is not listed on each vial
- PCCs are manufactured based on a factor IX assay, and the amount of factor II, VII, and X in a vial can vary considerably between products and between lots of the same product
- Elevated levels of factors II, VII, and IX may be associated with an increased risk of thromboembolic complications4
References: 1. Data on file, BPL-RD050-0515. 2. COAGADEX® (Coagulation Factor X, Human) Prescribing Information. Durham, NC: BPL Limited. 2015. 3. Brown DL, Kouides PA. Diagnosis and treatment of inherited factor X deficiency. Haemophilia. 2008;14(6):1176-82. 4. Menegatti M, Peyvandi F. Factor X deficiency. Semin Thromb Hemost. 2009;35:407-415.